People with Dupuytren`s contracture have an increased risk of developing other conditions in which similar connective tissue abnormalities affect other parts of the body. These include penis pads, which are nodules that develop on the ankles; Ledderos disease, also called plantar fibromatosis, which affects the feet; scar tissue in the shoulder that causes pain and stiffness (adhesive capsulitis or frozen shoulder); and in men, Peyronie`s disease, which causes an abnormal curvature of the penis. Although the cause of Dupuytren`s contracture is unknown, it is believed that changes in one or more genes affect the risk of developing this disorder. Some of the genes associated with the disease are involved in a biological process called the Wnt signaling pathway. This signaling pathway promotes the growth and division (proliferation) of cells and is involved in determining the specialized functions of a cell (differentiation). Symptoms of Dupuytren`s contracture are usually lumps, nodules, and ribbons or cords on the palmar side of the hands. Lumps are usually firm and stick to the skin of the palm. The skin may seem thicker and thicker. Think of the Dupuytren`s palm skin as a road. Some areas are swollen and inflated like a speed threshold. In other areas, the skin is pecked like a pothole and pulled down. Thick cords can develop from the palm of the hand to one or more fingers.

These cords can make the fingers bend. The ring finger and the little finger are most often involved. One or both hands may be affected. Each hand can be assigned according to a different pattern and at different times. Bumps can be uncomfortable in some people. However; In most people, Dupuytren`s contracture is usually not painful. The disease may be noticed first because it is difficult to place the hand flat on a surface (Figure 3) or to open the hand completely. It can be more difficult to wash your hands, wear gloves, hold large objects and put your hands in pockets. When it comes to the right hand, people may find it uncomfortable to shake hands. It is difficult to predict how the disease will progress. Some people have only small bumps or cords, while others develop strongly bent fingers. There are a variety of risk factors.

The disease tends to be more severe if it occurs at an earlier age. Men develop more severe symptoms than women. If you have many parents with the problem, you may be at greater risk for a more serious condition. If there are changes in other parts of the body, you are more at risk. This is called the Dupuytren diathesis. Bumps and cords can develop on the soles of the feet (plantar fibromatosis) or on the genital position in men (Peyronie`s disease). Sometimes the disease causes the ankles to thicken, called ankle pads (or garrod pads). People with severe impairment often have bumps in the back of their finger joints (called « garrod pads, » « ankle pads, » or « dorsal Dupuytren`s nodules ») and bumps in the arch of the foot (plantar fibromatosis or plush pants disease). [13] In severe cases, the area where the palm of the hand meets the wrist may develop bumps. It is believed that the condition of Peyronie`s disease is related to Dupuytren`s contracture. [14] Before aponevotomy, liposuction is performed on the abdomen and ipsilateral flank to collect lipograft. [50] Treatment can be performed under regional or general anesthesia.

The digits are placed under maximum extension voltage with a fixed hand retractor. The surgeon makes several palmar puncture wounds with small notches. Tension on the cords is crucial, as tight and constrictor ligaments are most likely to be cut and torn by small notches, while sparing relatively loose neurovascular structures. Once the cord is completely severed and separated from the skin, the lipograft is injected under the skin. In total, about 5-10 ml per jet is injected. [50] With dupuytren contracture, the palmar fascia of the hand becomes abnormally thick, which can lead to finger curling and impair finger function. The main function of the palmar fascia is to increase the grip strength; Thus, over time, dupuytren contracture reduces a person`s ability to hold objects and use the hand in many different activities. Dupuytren`s contracture can also be perceived as embarrassing in social situations and can affect quality of life[12] People may report pain, pain, and itching with contractions. .